Area Editoriale

Bella review sull'Emocromatosi

15 giugno 2004 | Epatologia

vito Scrive"Hereditary Hemochromatosis — A New Look at an Old DiseaseCHAR(13) + CHAR(10)Antonello PietrangeloCHAR(13) + CHAR(10)New Engl J Med, 2004;350:2383-2397CHAR(13) + CHAR(10)

For much of the 20th century, hereditary hemochromatosis was regarded as a clinically and genetically unique entity. The classic findings on presentation — diabetes, bronze pigmentation of the skin, and cirrhosis — were first described in the 19th century, when the term "hemochromatosis" was first used1,2,3; by 1935 it had become clear that the disease was hereditary and was caused by excess deposits of iron in the tissue.4 In the 1970s and 1980s, it was recognized as an autosomal recessive disorder linked to the region of the short arm of chromosome 6 .........
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